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An acute myopathy has been noticed with the use of excessive doses of corticosteroids, most frequently occurring in sufferers with problems of neuromuscular transmission (eg, myasthenia gravis), or in patients receiving concomitant therapy with neuromuscular blocking medication (eg, pancuronium).
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Extended systemic corticosteroid remedy can result in osteoporosis, vertebral compression fractures, aseptic necrosis of femoral and humoral heads, and pathologic fractures of long bones secondary to decreased bone formation, elevated bone resorption, and protein catabolism in any sufferers.
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